Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control

Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human \'superspreading' of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.

Bioethics: awareness, attitudes and opinions among University students and Faculty/researchers

To assess awareness, attitudes and opinions regarding bioethical issues among graduate students and faculty/researchers of universities in Lahore, Pakistan. A questionnaire consisting of 20 questions was designed and sent to 700 students and faculty members/researchers of 14 academic departments/research institutions of seven universities in Lahore, Pakistan. Data were analyzed with descriptive statistics using SPSS 16.0. We obtained responses from 87% [614/700] participants. The sample populations appeared receptive to latest developments in science and technology; and were optimistic that such developments will have positive effect on their lives. On average almost 90% of the respondents were familiar with the term "bioethics"; 75.4% of the respondents desired that bioethics should be taught regularly in the classes. However, students of two important disciplines of knowledge i.e law and Islamic studies had awareness levels of only 43% and '0'% respectively regarding the term bioethics. A vast majority of the respondents were not satisfied with the state laws, policies, rules, regulations and institutions concerned with bioethical issues. The survey indicated that cloning [27.2%], abortion [24.6%] and organ donation [13.2%] are regarded as the most important bioethical issues, probably for specific reasons of the glamour attached to the technology, moral connotations and the hype created by media respectively. Educated youth in general have positive attitude towards S and T and its effect on their lives. Awareness level among students and faculty of life sciences is very high; however it is dismally low among students of Law and Islamic studies. The results of this survey does not necessarily mirror the awareness level, attitudes and opinions in the society at large since literacy level among the masses is low [57%] and prevalence of higher levels of education is even lower